first of all

The content of any article needs, first of all, to be relevant to the reader.

首，任何文章的内容都必须适应读者的需要。

German unity depends first of all on the German people.

德国的统一首靠的是德国人民。

First of all, totally unlash yourself, face your work with a brand-new sight, and regard it as a good chance for practice.

首要做的第一件事是彻底放己，用全新的目光去面对你现在从事的工作，就当是一个学习磨练的好机会。